Redox Imbalance and Biochemical Changes in Cancer
نویسندگان
چکیده
منابع مشابه
Redox imbalance and biochemical changes in cancer.
For this article, we explore a hypothesis involving the possible role of reduction/oxidation (redox) state in cancer. We hypothesize that many modifications in cellular macromolecules, observed in cancer progression, may be caused by redox imbalance. Recent biochemical data suggest that human prostate cancer cell lines show a redox imbalance (oxidizing) compared with benign primary prostate epi...
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1Department of Neurology, Jinling Hospital, Medical School of Nanjing University, Nanjing 210002, China 2Department of Neurology, Xijing Hospital, The Fourth Military Medicine University, Xi’an 710032, China 3School of Dentistry, Cardiff Institute of Tissue Engineering and Repair, Cardiff University, Heath Park, Cardiff CF14 4XY, UK 4Department of Neurology, Henry Ford Hospital, Detroit, MI 482...
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Redox imbalance is resulted from the destruction of balance between oxidants and antioxidants. The dominant oxidants are reactive oxygen species (ROS), which are involved in multiple cellular processes by physiologically transporting signal as a second messenger or pathologically oxidizing DNA, lipids, and proteins. Generally speaking, low concentration of ROS is indispensable for cell survival...
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ژورنال
عنوان ژورنال: Cancer Research
سال: 2013
ISSN: 0008-5472,1538-7445
DOI: 10.1158/0008-5472.can-13-1117